One-pot synthesis of dihydroquinolones by sequential reactions of <i>o</i>-aminobenzyl alcohol derivatives with Meldrum's acids-Reference-Cited by-同舟云学术

One-pot synthesis of dihydroquinolones by sequential reactions of o-aminobenzyl alcohol derivatives with Meldrum's acids

Published:2022 Issue:15 Volume:20 Page:3160-3173
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Arcadi Antonio¹^ORCID,Calcaterra Andrea²^ORCID,Fabrizi Giancarlo²,Fochetti Andrea²^ORCID,Goggiamani Antonella²^ORCID,Iazzetti Antonia³^ORCID,Marrone Federico²,Mazzoccanti Giulia²^ORCID,Serraiocco Andrea²

Affiliation:

1. Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica, Università degli Studi di L'Aquila, Via Vetoio, 67100 Coppito, AQ, Italy

2. Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy

3. Dipartimento di Scienze Biotecnologiche di base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, L.go Francesco Vito 1, 00168 Rome, Italy

Abstract

The functionalized 3,4-dihydroquinolin-2-one nucleus has been assembled in good to high yields through the sequential reaction of readily available N-Ts-o-aminobenzyl alcohols with Meldrum's acid derivatives under mild basic conditions.

Funder

Sapienza Università di Roma

Università degli Studi dell'Aquila

Ministero dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00289B

Reference71 articles.

1. Lewis Acid Catalyzed Intramolecular [4+2] Cycloaddition of In Situ Generated Aza‐Quinone Methides for the Stereoselective Synthesis of Furo/pyrano[3,2‐ c ]tetrahydroquinolines