Discovery of a novel AcrAB-TolC pump inhibitor using the multistep virtual screening, synthesis and biological evaluation of asymmetric imidazole-4,5-dicarboxamide derivatives-Reference-Cited by-同舟云学术

Discovery of a novel AcrAB-TolC pump inhibitor using the multistep virtual screening, synthesis and biological evaluation of asymmetric imidazole-4,5-dicarboxamide derivatives

Published:2023 Issue:45 Volume:47 Page:20718-20722
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Phan Thien-Vy¹²,Huynh Phuong Nguyen Hoai¹,Nguyen Vu-Thuy-Vy¹²,Nguyen Thanh-Phuc¹,Vu Thanh-Thao¹,Thi Vo Cam-Van¹^ORCID,Le Minh-Tri¹³,Nguyen Bao Gia Dang⁴^ORCID,Truong Phuong¹,Thai Khac-Minh¹^ORCID

Affiliation:

1. Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang St., Dist. 1, Ho Chi Minh City 700000, Vietnam

2. Department of Pharmacy, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh St., Dist. 4, Ho Chi Minh City 700000, Vietnam

3. School of Medicine, Vietnam National University Ho Chi Minh City, Linh Trung Ward., Thu Duc Dist, Ho Chi Minh City, 700000, Vietnam

4. Imperial College London, London SW7 2AZ, UK

Abstract

By virtual screening, we identify the potential of asymmetric imidazole-4,5-dicarboxamide derivatives as E. coli-AcrB efflux pump inhibitors. The compounds are synthesized and their inhibitory activity is evaluated by a biological assay.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D3NJ01603J

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