Influence of membrane lipid composition on the structure and activity of γ-secretase
Author:
Affiliation:
1. Facultad de Química
2. Departamento de Fisicoquímica
3. Universidad Nacional Autónoma de México
4. Mexico City
5. Mexico
6. Department of Chemistry
7. Boston University
8. Boston
9. USA
Abstract
Insight into the effect of bilayer lipid composition on the GS structural ensemble and function using multiscale computational modeling approaches.
Funder
NIH Clinical Center
Consejo Nacional de Ciencia y Tecnología
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP04138E
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1. Proteolytic processing of Alzheimer’s β-amyloid precursor protein
2. BACE1 is the major β-secretase for generation of Aβ peptides by neurons
3. The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
4. Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane
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