Design and synthesis of spirooxindole–pyrrolidines embedded with indole and pyridine heterocycles by multicomponent reaction: anticancer and <i>in silico</i> studies-Reference-Cited by-同舟云学术

Design and synthesis of spirooxindole–pyrrolidines embedded with indole and pyridine heterocycles by multicomponent reaction: anticancer and in silico studies

Published:2022 Issue:21 Volume:46 Page:10089-10106
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Mayakrishnan Sivakalai¹^ORCID,Kathirvelan Devarajan²^ORCID,Arun Yuvaraj¹^ORCID,Saranraj Krishnan³,Balachandran Chandrasekaran⁴,Aoki Shin⁴,Yuvaraj Pannerselvam⁵^ORCID,Maheswarai Narayanan Uma¹^ORCID

Affiliation:

1. Organic & Bioorganic Chemistry, CSIR-Central Leather Research Institute, Adyar, Chennai 600020, India

2. Department of Chemistry, Indian Institute of Technology, Hyderabad 502 285, India

3. Department of Physical Chemistry, Madurai Kamaraj University, Madurai 625 021, India

4. Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda 278-8510, Japan

5. CSIR-North East Institute of Science & Technology (NEIST), Branch Laboratory, Imphal-795004, Manipur, India

Abstract

We report the synthesis of spirooxindole–pyrrolidines tethered with indole and pyridine heterocycles using 1,3-dipolar cycloaddition, and their anticancer activities and molecular docking studies.

Funder

Council of Scientific and Industrial Research, India

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ05839H

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