Transition-metal free selective C(α)–C(β) bond cleavage of trifluoromethyl ketones with amidines under air: facile access to 5-trifluoromethylated Imidazol-4-ones-Reference-Cited by-同舟云学术

Transition-metal free selective C(α)–C(β) bond cleavage of trifluoromethyl ketones with amidines under air: facile access to 5-trifluoromethylated Imidazol-4-ones

Published:2019 Issue:6 Volume:6 Page:858-862
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhu Chuanle¹²³⁴⁵^ORCID,Liu Chi¹²³⁴⁵,Zeng Hao¹²³⁴⁵,Chen Fulin¹²³⁴⁵,Jiang Huanfeng¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Functional Molecular Engineering of Guangdong Province

2. School of Chemistry and Chemical Engineering

3. South China University of Technology

4. Guangzhou 510640

5. China

Abstract

Synthesis of 5-trifluoromethylated imidazol-4-ones via transition-metal-free selective C(α)–C(β) bond cleavage of trifluoromethyl ketones with amidines under air.

Funder

National Natural Science Foundation of China

Pearl River S and T Nova Program of Guangzhou

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/QO/C9QO00029A

Reference54 articles.

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2. I. Ojima , Fluorine in Medicinal Chemistry and Chemical Biology , Wiley-Blackwell , Chichester , 2009