A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells-Reference-Cited by-同舟云学术

A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

Published:2016 Issue:46 Volume:52 Page:7380-7383
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Liu Peng-Yun¹²³⁴,Li Shing-To¹²³⁴,Shen Fang-Fang¹²³⁴,Ko Wing-Hung⁵⁶⁴,Yao Xiao-Qiang⁵⁶⁴,Yang Dan¹²³⁴

Affiliation:

1. Morningside Laboratory for Chemical Biology

2. Department of Chemistry

3. The University of Hong Kong

4. P. R. China

5. School of Biomedical Sciences

6. The Chinese University of Hong Kong

Abstract

A C₂ symmetric small molecule composed of l-phenylalanine and isophthalamide was found to function as a Cl⁻/HCO₃⁻ dual transporter and self-assemble into chloride channels.

Funder

Research Grants Council, University Grants Committee, Hong Kong

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC01964A

Reference26 articles.

1. Why bicarbonate?This paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.

2. Bicarbonate transport proteins

3. Bicarbonate transport in cell physiology and disease

4. Aberrant CFTR-dependent HCO-3 transport in mutations associated with cystic fibrosis

5. The Structure of a Cyanobacterial Bicarbonate Transport Protein, CmpA

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