Exploration and characterization of a novel cocrystal hydrate consisting of captopril, an amino acid-derived drug-Reference-Cited by-同舟云学术

Exploration and characterization of a novel cocrystal hydrate consisting of captopril, an amino acid-derived drug

Published:2023 Issue:17 Volume:25 Page:2523-2533
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Haku Ryotaro¹,Takatori Kazuhiko²^ORCID,Suzuki Naoto³^ORCID,Ono Makoto¹,Titapiwatanakun Varin⁴^ORCID,Fukami Toshiro¹^ORCID

Affiliation:

1. Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

2. Department of Synthetic Organic Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

3. Laboratory of Pharmaceutics, School of Pharmacy, Nihon University, 7-7-7 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan

4. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok 10330, Thailand

Abstract

We found a novel cocrystal consisting of captopril, which is an amino acid-derived drug having a thiol group, and l-proline by using nano-spot-screening with LF-Raman. This cocrystal hydrate showed high hygroscopicity resulted from changes in intermolecular interactions.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CE/D3CE00181D

Reference41 articles.

1. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

2. Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol

3. Proniosomal Powder of Captopril: Formulation and Evaluation

4. Factors affecting captopril stability in aqueous solution

5. Physical stability enhancement of theophylline via cocrystallization

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