One-pot multi-step cascade protocols toward β-indolyl sulfoximidoyl amides via intermolecular trapping of an α-indolylpalladium complex by CO-Reference-Cited by-同舟云学术

One-pot multi-step cascade protocols toward β-indolyl sulfoximidoyl amides via intermolecular trapping of an α-indolylpalladium complex by CO

Published:2021 Issue:15 Volume:19 Page:3359-3369
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Huahua¹²³⁴⁵,Wei Li¹²³⁴⁵,Chen Zhiyuan¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Functional Small Organic Molecules

2. Ministry of Education and Jiangxi Key Laboratory of Green Chemistry

3. College of Chemistry & Chemical Engineering

4. Jiangxi Normal University

5. Nanchang

Abstract

Various β-indolyl sulfoximidoyl amides were efficiently prepared from ortho-iodoanilines, propargyl bromides, 1 atm of CO, and NH-sulfoximines, through a palladium-catalyzed indole annulation/carbonyl insertion/C–N bond formation cascade.

Funder

Education Department of Jiangxi Province

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00128K

Reference72 articles.

1. Sulfoximines from a Medicinal Chemist's Perspective: Physicochemical and in vitro Parameters Relevant for Drug Discovery

2. Sulfoximines: A Neglected Opportunity in Medicinal Chemistry

3. Straightforward Strategies for the Preparation of NH-Sulfoximines: A Serendipitous Story

4. Recent Achievements in the Synthesis of Sulfoximine Derivatives

5. Drug discovery and commercial exploitation

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