Rational design, preparation and characterization of recombinant Ag85B variants and their glycoconjugates with T-cell antigenic activity againstMycobacterium tuberculosis-Reference-Cited by-同舟云学术

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Rational design, preparation and characterization of recombinant Ag85B variants and their glycoconjugates with T-cell antigenic activity againstMycobacterium tuberculosis

Published:2018 Issue:41 Volume:8 Page:23171-23180
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Rinaldi Francesca¹²³⁴,Tengattini Sara¹²³⁴,Piubelli Luciano⁵⁶⁷⁴⁸,Bernardini Roberta⁹¹⁰¹¹⁴,Mangione Francesca¹²³⁴,Bavaro Teodora¹²³⁴,Paone Gregorino¹³¹⁴¹⁵¹⁶⁴,Mattei Maurizio⁹¹⁰¹¹⁴,Pollegioni Loredano⁵⁶⁷⁴⁸,Filice Gaetano¹⁷¹⁸¹⁹³⁴,Temporini Caterina¹²³⁴^ORCID,Terreni Marco¹²³⁴

Affiliation:

1. Department of Drug Sciences

2. University of Pavia

3. 27100 Pavia

4. Italy

5. Department of Biotechnology and Life Sciences

6. University of Insubria

7. 21100 Varese

8. The Protein Factory Research Centre

9. Department of Biology and Animal Technology Station

10. University of Rome “Tor Vergata”

11. 00133 Rome

12. IRCCS San Matteo Hospital Foundation Microbiology and Virology Unit

13. Department of Cardiovascular

14. Respiratory, Nephrologic, Anesthesiologic and Geriatric Sciences

15. Sapienza University of Rome

16. 00185 Rome

17. Department of Internal Medicine and Therapeutics

18. University of Pavia and Unit of Infectious Diseases

19. IRCCS San Matteo Hospital Foundation

Abstract

Recombinant Ag85B variants were designed and prepared to improve the immunogenicity of a potential glycoconjugate vaccine against tuberculosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA03535K

Reference49 articles.

1. Carbohydrate vaccines: developing sweet solutions to sticky situations?

2. Synthetically defined glycoprotein vaccines: current status and future directions

3. Glycoconjugate vaccines: an update

4. Efficacy of a Conjugate Vaccine Containing Polymannuronic Acid and Flagellin against Experimental Pseudomonas aeruginosa Lung Infection in Mice

5. From new Diagnostic Targets to Recombinant Proteins and Semi-Synthetic Protein-Based Vaccines

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1. Recent efforts in the development of glycoconjugate vaccine and available treatment for tuberculosis;Bioorganic Chemistry;2024-09

2. Effect of glycosylation on the affinity of the MTB protein Ag85B for specific antibodies: towards the design of a dual-acting vaccine against tuberculosis;Biology Direct;2024-01-25

3. Glycovaccine Design: Optimization of Model and Antitubercular Carrier Glycosylation via Disuccinimidyl Homobifunctional Linker;Pharmaceutics;2023-04-23

4. Design of epidermal growth factor immobilization on 3D biocompatible scaffolds to promote tissue repair and regeneration;Scientific Reports;2021-01-29

5. Novel Vaccine Candidates against Tuberculosis;Current Medicinal Chemistry;2020-09-11

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