Post-synthesis DNA modifications using a trans-cyclooctene click handle-Reference-Cited by-同舟云学术

Post-synthesis DNA modifications using a trans-cyclooctene click handle

Published:2015 Issue:3 Volume:13 Page:909-915
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Ke¹²³⁴⁵,Wang Danzhu¹²³⁴⁵,Ji Kaili¹²³⁴⁵,Chen Weixuan¹²³⁴⁵,Zheng Yueqin¹²³⁴⁵,Dai Chaofeng¹²³⁴⁵,Wang Binghe¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Center for Diagnostics and Therapeutics

3. Georgia State University

4. Atlanta

5. USA

Abstract

Efficient enzymatic DNA incorporation of trans-cyclooctene thymidine triphosphate (TCO-TTP) is reported. The general handle of trans-cyclooctene can undergo a rapid bioorthogonal cycloaddition with tetrazine, which is suitable for further DNA labeling work.

Funder

U.S. Department of Health and Human Services

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02031F

Reference49 articles.

1. Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles

2. Electrochemical DNA sensors

3. Folding DNA to create nanoscale shapes and patterns