Effects of fluorine substitution on substrate conversion by cytochromes P450 17A1 and 21A2-Reference-Cited by-同舟云学术

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Effects of fluorine substitution on substrate conversion by cytochromes P450 17A1 and 21A2

Published:2021 Issue:35 Volume:19 Page:7664-7669
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Vogt Caleb D.¹,Bart Aaron G.²,Yadav Rahul²,Scott Emily E.²³,Aubé Jeffrey¹^ORCID

Affiliation:

1. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina 27599, USA

2. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA

3. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA

Abstract

Cytochromes P450 17A1 (CYP7A1) and 21A2 (CYP21A2) catalyze key reactions in the production of steroid hormones, including mineralocorticoids, glucocorticoids, and androgens.

Funder

National Cancer Institute

Division of Chemistry

National Institute of General Medical Sciences

Eshelman Institute for Innovation, University of North Carolina at Chapel Hill

University of Michigan

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01178B

Reference26 articles.

1. The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

2. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review

3. Targeting CYP17: established and novel approaches in prostate cancer

4. CYP17A1: A Biochemistry, Chemistry, and Clinical Review

5. Applications of Fluorine in Medicinal Chemistry

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1. Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450;Biomolecules;2024-02-08

2. Speciation and kinetics of fluoride transfer from tetra-n-butylammonium difluorotriphenylsilicate (‘TBAT’);Chemical Science;2024

3. Development of a carbazole-based fluorescent probe for quantitative detection of fluoride ions in aqueous systems;Chemical Papers;2022-10-27

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