Dynamics of force generation by spreading platelets

Author:

Hanke Jana123,Probst Dimitri45365,Zemel Assaf78,Schwarz Ulrich S.45365ORCID,Köster Sarah123910ORCID

Affiliation:

1. Institute for X-Ray Physics, University of Goettingen, Friedrich-Hund-Platz 1

2. 37077 Göttingen

3. Germany

4. Institute for Theoretical Physics, Heidelberg University

5. Heidelberg

6. BioQuant-Center for Quantitative Biology, Heidelberg University

7. Institute of Dental Sciences and Fritz Haber Center for Molecular Dynamics, Hebrew University of Jerusalem

8. Israel

9. German Center for Cardiovascular Research (DZHK)

10. Partner Site Göttingen

Abstract

Using time-resolved traction force microscopy on soft elastic substrates of variable stiffness, here we show that human platelets generate highly dynamic force patterns and an exceptionally high level of internal stress.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

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