Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells

Author:

Geninatti Crich S.123,Cadenazzi M.123,Lanzardo S.123,Conti L.123,Ruiu R.123,Alberti D.123,Cavallo F.123,Cutrin J. C.123,Aime S.123

Affiliation:

1. University of Turin

2. Department of Molecular Biotechnology and Health Sciences

3. Torino, Italy

Abstract

Horse Spleen Apoferritin has been exploited to deliver simultaneously therapeutic and imaging agents to breast cancer cells via the ferritin transporting route. The selective uptake has been investigated by MRI, and exploited for the simultaneous delivery of Curcumin, a compound with strong anti-neoplastic and anti-inflammatory action.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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