Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1-Reference-Cited by-同舟云学术

Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1

Published:2014 Issue:9 Volume:5 Page:1290-1296
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Humphrey John M.¹²³,Yang Eddie¹²³,Ende Christopher W. am¹²³,Arnold Eric P.¹²³,Head Jenna L.¹²³,Jenkinson Stephen⁴²⁵⁶,Lebel Lorraine A.¹²³,Liras Spiros²⁷,Pandit Jayvardhan¹²³,Samas Brian¹²³,Vajdos Felix¹²³,Simons Samuel P.¹²³,Evdokimov Artem¹²³,Mansour Mahmoud¹²³,Menniti Frank S.⁸⁹

Affiliation:

1. Neuroscience Medicinal Chemistry

2. Pfizer World Wide Research and Development

3. Groton, USA

4. Safety Pharmacology CoE

5. 10646 Science Center Drive

6. San Diego, USA

7. Cambridge, USA

8. Pharmaceuticals, Inc. One Davol Square

9. Providence, USA

Abstract

We describe the discovery of potent, selective, brain penetrable quinazoline inhibitors of PDE1 that represent valuable new tools for the dissection of related biological events.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C4MD00113C

Reference28 articles.

1. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

2. Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling

3. Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling

4. Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

5. Phosphodiesterases in the CNS: targets for drug development

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