Towards efficient Ir(<scp>iii</scp>) anticancer photodynamic therapy agents by extending π-conjugation on N^N ligands-Reference-Cited by-同舟云学术

Towards efficient Ir(iii) anticancer photodynamic therapy agents by extending π-conjugation on N^N ligands

Published:2024 Issue:27 Volume:53 Page:11393-11409
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sanz-Villafruela Juan¹^ORCID,Bermejo-Casadesús Cristina²^ORCID,Martínez-Alonso Marta¹,Moro Artur³,Lima João C.³^ORCID,Massaguer Anna²^ORCID,Espino Gustavo¹^ORCID

Affiliation:

1. Universidad de Burgos, Departamento de Química, Facultad de Ciencias, Plaza Misael Bañuelos s/n, 09001, Burgos, Spain

2. Universitat de Girona, Departament de Biologia, Facultat de Ciències, Maria Aurelia Capmany 40, 17003 Girona, Spain

3. Universidade NOVA de Lisboa, LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, 2829-516 Caparica, Portugal

Abstract

By extending π-conjugation on the N^N ligand, we have found an efficient Ir(iii) photosensitizer for anticancer PDT, which shows a long-lived excited state, excellent 1O2 production and mitochondrial membrane depolarization activity.

Funder

Universidad de Burgos

Universitat de Girona

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D4DT00390J

Reference68 articles.

1. Chemophototherapy: An Emerging Treatment Option for Solid Tumors

2. Predictive Strength of Photophysical Measurements for in Vitro Photobiological Activity in a Series of Ru(II) Polypyridyl Complexes Derived from π-Extended Ligands

3. Synergization of an endoplasmic reticulum-targeted iridium(III) photosensitizer with PD-L1 inhibitor for oral squamous cell carcinoma immunotherapy

4. In Vitro Multiwavelength PDT with 3IL States: Teaching Old Molecules New Tricks

5. Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy