N-Alkylated aziridines are easily-prepared, potent, specific and cell-permeable covalent inhibitors of human β-glucocerebrosidase-Reference-Cited by-同舟云学术

N-Alkylated aziridines are easily-prepared, potent, specific and cell-permeable covalent inhibitors of human β-glucocerebrosidase

Published:2015 Issue:57 Volume:51 Page:11390-11393
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Adams B. T.¹²³,Niccoli S.⁴⁵⁶⁷,Chowdhury M. A.¹²³,Esarik A. N. K.¹²³,Lees S. J.⁴⁵⁶⁷,Rempel B. P.⁸⁹¹⁰¹¹³,Phenix C. P.¹²³⁴⁵

Affiliation:

1. Thunder Bay Regional Research Institute

2. Ontario

3. Canada

4. Northern Ontario School of Medicine

5. Thunder Bay Campus

6. Thunder Bay Ontario

7. Canada P7B 5E1

8. Department of Science

9. Augustana Faculty

10. University of Alberta

11. Alberta

Abstract

N-Octyl conduritol aziridine is a potent and specific covalent inactivator of β-glucocerebrosidase (GBA1) inside live human cells.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC03828F

Reference33 articles.

1. Rational design of potent sialidase-based inhibitors of influenza virus replication

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