Enhanced H-bonding and π-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue-Reference-Cited by-同舟云学术

Enhanced H-bonding and π-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue

Published:2014 Issue:10 Volume:5 Page:3836-3844
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Lou Chenguang¹²³⁴,Dallmann Andre⁵⁶⁷⁸⁹,Marafini Pietro¹²³⁴¹⁰,Gao Rachel¹²³⁴,Brown Tom¹²³⁴¹⁰

Affiliation:

1. School of Chemistry

2. University of Southampton

3. Highfield

4. Southampton SO17 1BJ, UK

5. Institute of Structural Biology

6. Helmholtz Zentrum München, 85764 Neuherberg, Germany

7. Center for Integrated Protein Science Munich and Chair of Biomolecular NMR

8. TU München

9. 85747 Garching, Germany

10. Department of Chemistry

Abstract

Combining enhanced π-stacking, H-bonding and electrostatic attraction in a single C-monomer greatly increases DNA duplex stability and massively destabilises mismatches.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC00948G

Reference50 articles.

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