Beta-hydroxy beta-methyl butyrate decreases muscle protein degradation via increased Akt/FoxO3a signaling and mitochondrial biogenesis in weanling piglets after lipopolysaccharide challenge

Author:

Duan Yehui12345ORCID,Zheng Changbing12345,Zhong Yinzhao12345,Song Bo12345,Yan Zhaoming12345,Kong Xiangfeng12345,Deng Jinping6789,Li Fengna12345,Yin Yulong12345

Affiliation:

1. Key Laboratory of Agro-ecological Processes in Subtropical Region

2. Institute of Subtropical Agriculture

3. Chinese Academy of Sciences; Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production; Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central

4. Ministry of Agriculture

5. Changsha 410125

6. Guangdong Provincial Key Laboratory of Animal Nutrition Regulation

7. South China Agricultural University

8. Guangzhou

9. China

Abstract

The aim of this study was to investigate the effects of dietary β-hydroxy-β-methylbutyrate (HMB) on lipopolysaccharide (LPS)-induced muscle atrophy and to investigate the mechanisms involved.

Funder

National Natural Science Foundation of China

Science and Technology Department of Guangxi Zhuang Autonomous

National Basic Research Program of China

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Hunan Provincial Science and Technology Department

Earmarked Fund for China Agriculture Research System

Guangdong Academy of Sciences

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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