Synthesis of imidazoles via cascade reaction of nitroallylic acetates with amidines and studies on their trypanocidal activity
Author:
Affiliation:
1. Indian Institute of Technology Bombay
2. Mumbai 400 076
3. India
4. Oswaldo Cruz Institute
5. Rio de Janeiro
6. Brazil
7. Institute of Exact Sciences
8. Department of Chemistry
9. Federal University of Minas Gerais
10. Belo Horizonte
Abstract
Functionalized imidazoles derived from nitroallylic acetates and amidines exhibit potent activity against T. cruzi, the etiological agent of Chagas disease.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02561J
Reference71 articles.
1. L. D. Quin and J. A.Tyrell, Fundamentals of Heterocyclic Chemistry: Importance in Nature and in the Synthesis of Pharmaceuticals, John Wiley & Sons, Hoboken, New Jersey, 2010
2. K. Hofmann , in The Chemistry of Heterocyclic Compounds: Imidazole and Its Derivatives, Part I, ed. A. Weissberger, Wiley Interscience, New York, 1953
3. A Review on Biological Activity of Imidazole and Thiazole Moieties and their Derivatives
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