Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling-Reference-Cited by-同舟云学术

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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Zaman Shadid U.¹,Pagare Piyusha P.¹,Ma Hongguang¹,Hoyle Rosalie G.¹,Zhang Yan¹^ORCID,Li Jiong¹²³^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298-0540, USA

2. Department of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298-0540, USA

3. Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298-0540, USA

Abstract

We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.

Funder

Virginia Commonwealth University

Common Fund

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00122B

Reference50 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

3. Molecular Genetics of Colorectal Cancer

4. Comprehensive molecular characterization of human colon and rectal cancer

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