Cu2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation-Reference-Cited by-同舟云学术

Cu2+-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation

Published:2021 Issue:3 Volume:57 Page:379-382
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cristóvão Joana S.¹²³⁴⁵,Moreira Guilherme G.¹²³⁴⁵^ORCID,Rodrigues Filipe E. P.¹²³⁴⁵,Carapeto Ana P.¹²³⁴⁵,Rodrigues Mário S.¹²³⁴⁵,Cardoso Isabel⁶⁷⁸⁵⁹,Ferreira António E. N.¹⁰²¹¹¹²⁵,Machuqueiro Miguel¹²³⁴⁵,Fritz Guenter¹³¹⁴¹⁵¹⁶,Gomes Cláudio M.¹²³⁴⁵^ORCID

Affiliation:

1. Biosystems and Integrative Sciences Institute

2. Faculdade de Ciências

3. Universidade de Lisboa

4. Lisboa 1749-016

5. Portugal

6. IBMC – Instituto de Biologia Molecular e Celular

7. Universidade do Porto

8. Porto

9. i3S – Instituto de Investigação e Inovação em Saúde

10. Dep. Chemistry and Biochemistry

11. Universidade Lisboa

12. Lisbon

13. Institute of Microbiology

14. University of Hohenheim

15. Stuttgart 70599

16. Germany

Abstract

A mechanism of chemical regulation of the S100B chaperone via Cu²⁺ induced assembly of S100B cross-linked oligomers with enhanced anti-amyloid aggregation activity.

Funder

Fundação para a Ciência e a Tecnologia

Fundação Bial

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC06842J

Reference33 articles.

1. Alzheimer's disease

2. Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)

3. Chaperones in Neurodegeneration

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