3D micromixer for nanoliposome synthesis: a promising advance in high mass productivity

Author:

Firmino Priscilla C. O. S.12345ORCID,Vianna Sávio S. V.62345ORCID,da Costa Ohanna M. M. M.7845ORCID,Malfatti-Gasperini Antônio A.7845ORCID,Gobbi Angelo L.9845ORCID,Lima Renato S.984510ORCID,de la Torre Lucimara G.12345ORCID

Affiliation:

1. Department of Materials and Bioprocess Engineering

2. School of Chemical Engineering

3. University of Campinas (UNICAMP)

4. Campinas

5. Brazil

6. Department of Chemical Systems Engineering

7. Brazilian Synchrotron Light Laboratory (LNLS)

8. Brazilian Center for Research in Energy and Materials (CNPEM)

9. Brazilian Nanotechnology National Laboratory (LNNano)

10. Institute of Chemistry

Abstract

Synthesis of unilamellar and highly monodisperse liposomes in a 3D chaotic-advection microdevice. Process of high mass productivity in which mixing conditions are not the only parameter to control liposome synthesis.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference58 articles.

1. Microfluidic methods for forming liposomes

2. Thermodynamics and kinetics of vesicles formation processes

3. D. D. Lasic , Applications of Liposomes, in Handbook of Biological Physics , ed. R. Lipowsky and E. Sachnann , Elsevier Science B.V. , California, USA , 1995 , ch. 10, vol. 1 , pp. 419–519

4. Liposome production by microfluidics: potential and limiting factors

5. Diffusion of univalent ions across the lamellae of swollen phospholipids

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