Design and synthesis of novel monoterpenoid indole alkaloid-like analogues and their antitumour activities in vitro-Reference-Cited by-同舟云学术

Design and synthesis of novel monoterpenoid indole alkaloid-like analogues and their antitumour activities in vitro

Published:2018 Issue:16 Volume:16 Page:3026-3037
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fang Jiaqi¹²³⁴⁵,Huang Tao¹²³⁴⁵,Xia Mengyuan⁶⁷⁸⁹,Deng Lulu¹²³⁴⁵,Hao Xiaojiang¹²³⁴⁵,Wang Yuehu⁶⁷⁸⁹,Mu Shuzhen¹²³⁴^ORCID

Affiliation:

1. State Key Laboratory of Functions and Applications of Medicinal Plants

2. Guizhou Medical University

3. Guiyang 550014

4. PR China

5. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences

6. Kunming Institute of Botany

7. Chinese Academy of Sciences

8. Kunming 650201

9. P. R. China

Abstract

34 novel monoterpenoid indole alkaloid analogues were synthesized based on combinatorial chemistry strategy. Compound 18 was found to be the most promising antitumour lead compound.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00677F

Reference34 articles.

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4. Natural Products as Sources of New Drugs over the Last 25 Years

5. Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

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