Ciprofloxacin peptide-based nanoparticles confer antimicrobial efficacy against multidrug-resistant bacteria

Author:

Zhen Jian-Bin1ORCID,Yi Jia-Jia2,Liu Bing-Xiao1ORCID,Liu Yan-Jun1,Bu Xin-Yi1,Wu Xiao-Jing1,Tang Da3

Affiliation:

1. Department of Materials Engineering, Taiyuan Institute of Technology, Taiyuan 030008, China

2. College of Chemical Engineering and Technology, Taiyuan University of Technology, Taiyuan 030600, China

3. Chongqing Academy of Animal Science, Chongqing, 408599, China

Abstract

Positively charged PAC-NPs destroy the membrane potential through nonspecific electrostatic interactions. Hydrophobic ciprofloxacin also exerts synergistic antibacterial effects. The physical and chemical sterilization methods of PAC-NPs could prevent bacteria from developing drug-resistance.

Funder

Applied Basic Research Project of Shanxi Province, China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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