Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence

Author:

Zhang Ye12345,Zheng Tian-Lu12345,Cheng Fu12345,Dai Kun-Long12345,Zhang Kun6785,Ma Ai-Jun6785,Zhang Fu-Min12345ORCID,Zhang Xiao-Ming12345ORCID,Wang Shao-Hua12345ORCID,Tu Yong-Qiang12345ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry

2. School of Pharmacy

3. Lanzhou University

4. Lanzhou 730000

5. P. R. China

6. School of Biotechnology and Health Science

7. Wuyi University

8. Jiangmen 529020

Abstract

An efficient construction of spirocyclo[4.5]decane derivatives is developed via a Castro–Stephens coupling/1,3-acyloxy shift/cyclization/semipinacol rearrangement sequence.

Funder

National Natural Science Foundation of China

Project 211

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

Department of Education of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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