Design, synthesis and antitumor study of novel NO-type porphyrin–ferulic acid derivatives for chemotherapy and photodynamic therapy

Author:

Liu Zhenhua12,Yang Lingyan12,Tian Zejie12,Li Hui12,Shi Lei12,Tang Chen12,Guo Yu12ORCID,He Jun3,Liu Yunmei12ORCID

Affiliation:

1. Institute of Pharmacy & Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang City, Hunan Province, 421001, P. R. China

2. Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, 28 Western Changshen Road, Hengyang City, Hunan Province, 421001, P. R. China

3. Institute of Chemistry & Chemical Engineering, University of South China, Hengyang City, Hunan Province, 421001, P. R. China

Abstract

NO-type porphyrin-ferulic acid derivatives were obtained by combining NO donor, ferulic acid, and porphyrin. It can realize the combined treatment of phototherapy and chemotherapy and effectively kill cancer cells.

Publisher

Royal Society of Chemistry (RSC)

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