A senolysis-based theragnostic prodrug strategy towards chronic renal failure

Author:

Song Yihe1ORCID,Li Xinming1ORCID,Shi Donglei12ORCID,Sun Tianyue1ORCID,Liu Wenwen3ORCID,Li Xiaokang1ORCID,Qiao Sicong1ORCID,Chen Xin1ORCID,Guo Yuan2ORCID,Li Jian1345ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

2. Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China

3. Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Pharmacy, Hainan University, Haikou 570228, Hainan, China

4. Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200092, China

5. Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan, College of Pharmacy, Dali University, Dali 671000, China

Abstract

Here, we report a senescence-associated β-galactosidase activatable theragnostic prodrug to pertinently treat chronic renal failure (CRF) in mice with the aid of fluorescence-guided senolysis, providing a creative molecular approach to CRF therapy.

Funder

National Natural Science Foundation of China

Shanghai Municipal Education Commission

State Key Laboratory of Bioreactor Engineering

Natural Science Basic Research Program of Shaanxi Province

National Postdoctoral Program for Innovative Talents

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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