Synthesis of β- and γ-lactam fused dihydropyrazinones from Ugi adducts via a sequential ring construction strategy-Reference-Cited by-同舟云学术

Synthesis of β- and γ-lactam fused dihydropyrazinones from Ugi adducts via a sequential ring construction strategy

Published:2020 Issue:84 Volume:56 Page:12789-12792
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Singh Sangh Priya¹²³⁴⁵,Tripathi Shashank¹²³⁴⁵,Yadav Anamika¹²³⁴⁵,Kant Ruchir⁶²³⁴,Srivastava Hemant Kumar⁷⁸⁹⁴^ORCID,Srivastava Ajay Kumar¹²³⁴⁵^ORCID

Affiliation:

1. Medicinal and Process Chemistry Division

2. CSIR-Central Drug Research Institute

3. Lucknow-226031

4. India

5. Chemical Sciences Division

6. Molecular and Structural Biology Division

7. Department of Medicinal Chemistry

8. National Institute of Pharmaceutical Education and Research

9. Guwahati-781101

Abstract

An efficient and novel method for the synthesis of bicyclic lactams is reported via post-Ugi functionalization.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC04415F

Reference36 articles.

1. An update on β-lactamase inhibitor discovery and development

2. Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

3. Exploring the chemical space and the bioactivity profile of lactams: a chemoinformatic study

4. Overcoming Resistance to β-Lactam Antibiotics

5. Bifunctional N-Heterocyclic Carbene-Catalyzed Highly Enantioselective Synthesis of Spirocyclic Oxindolo-β-lactams

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