Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance-Reference-Cited by-同舟云学术

Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance

Published:2016 Issue:7 Volume:7 Page:4117-4124
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chow Mun Juinn¹²³⁴⁵,Licona Cynthia⁶⁷⁸⁹¹⁰,Pastorin Giorgia⁴⁵¹¹²³,Mellitzer Georg⁶⁷⁸⁹¹⁰,Ang Wee Han¹²³⁴⁵^ORCID,Gaiddon Christian⁶⁷⁸⁹¹⁰

Affiliation:

1. Department of Chemistry

2. National University of Singapore

3. 117543 Singapore

4. NUS Graduate School for Integrative Sciences and Engineering

5. Singapore

6. U1113 INSERM

7. Strasbourg 67200

8. France

9. Section Oncology

10. FMTS

11. Department of Pharmacy

Abstract

Varying the arene ligand on organoruthenium compounds induced the differential activation of ER stress pathways, leading to non-apoptotic programmed cell death and bypassing drug resistance mechanisms.

Funder

Centre National de la Recherche Scientifique

Ministry of Education - Singapore

Ligue Contre le Cancer

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00268D

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