A novel DNA biosensor for the ultrasensitive detection of DNA methyltransferase activity based on a high-density “hot spot” SERS substrate and rolling circle amplification strategy-Reference-Cited by-同舟云学术

A novel DNA biosensor for the ultrasensitive detection of DNA methyltransferase activity based on a high-density “hot spot” SERS substrate and rolling circle amplification strategy

Published:2021 Issue:17 Volume:146 Page:5326-5336
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Ge Shengjie¹²³,Ran Menglin⁴,Mao Yu¹²³,Sun Yue¹²³,Zhou Xinyu¹²³,Li Li⁵^ORCID,Cao Xiaowei¹²³^ORCID

Affiliation:

1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225001, P. R. China

2. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou, P. R. China

3. Jiangsu Key Laboratory of Experimental & Translational Noncoding RNA Research, Medical College, Yangzhou University, Yangzhou, China

4. The First Clinical College, Dalian Medical University, Dalian, P. R. China

5. Children's Hospital of Nanjing Medical University, Nanjing, P. R. China

Abstract

Herein, a novel biosensor based on a high-density “hot spot” Au@SiO2 array SERS substrate and rolling circle amplification (RCA) strategy for the ultrasensitive detection of CpG methyltransferase (M.SssI) activity was devoloped.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/AN/D1AN01034D

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4. DNA methylation and hydroxymethylation associated with gene expression regulatory network during 3-methylcholanthrene induced lung cell malignant transformation

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