Multi-arm ε-polylysines exhibit broad-spectrum antifungal activities against <i>Candida</i> species-Reference-Cited by-同舟云学术

Multi-arm ε-polylysines exhibit broad-spectrum antifungal activities against Candida species

Published:2023 Issue:23 Volume:11 Page:7588-7597
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Cao Yuanqiao¹²,Liu Ming¹,Han Miaomiao¹,Ji Shengxiang¹²^ORCID

Affiliation:

1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, P. R. China

2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, P. R. China

Abstract

Multi-arm ε-polylysines (ε-mPLs, nR-Km) exhibit broad-spectrum antifungal activities and excellent biocompatibility. Mechanistic studies suggest that 3R-K7 kills fungi through entering the cells to generate ROS and induce cell apoptosis.

Funder

National Key Research and Development Program of China

Jilin Scientific and Technological Development Program

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D3BM01233F

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