Two populations of protein molecules detected by small-angle neutron and X-ray scattering (SANS and SAXS) in lyophilized protein:lyoprotector (disaccharide) systems-Reference-Cited by-同舟云学术

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Two populations of protein molecules detected by small-angle neutron and X-ray scattering (SANS and SAXS) in lyophilized protein:lyoprotector (disaccharide) systems

Published:2024 Issue:19 Volume:20 Page:3897-3900
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Cristiglio Viviana¹^ORCID,Feng Shaoxin²,Sztucki Michael³,Yuan Xiaoda⁴,Shalaev Evgenyi⁵^ORCID

Affiliation:

1. Institut Laue-Langevin, 71 Av des Martyrs, Grenoble 38042, France

2. Research and Development, AbbVie Inc, Irvine, CA 92612, USA

3. European Synchrotron Radiation Facility (ESRF), 71 Av des Martyrs, Grenoble 38043, France

4. Research and Development, AbbVie Inc., 2525 Dupont Drive, Irvine, CA 92612, USA

5. Research and Development, AbbVie Inc., 2525 Dupont Dr, Irvine, CA 92612, USA

Abstract

Two protein interaction peaks are observed in pharmaceutically-relevant protein (serum albumin) : disaccharide 1 : 1 and 1 : 3 (w/w) freeze-dried systems for the first time.

Funder

Institut Laue-Langevin

European Synchrotron Radiation Facility

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SM/D4SM00028E

Reference28 articles.

1. The Pharmaceutical Industry in 2022: An Analysis of FDA Drug Approvals from the Perspective of Molecules

2. Stabilization of proteins in solid form

3. Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

4. Stabilizing vaccines via drying: Quality by design considerations

5. Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses

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