Synthesis of fused 3-trifluoromethyl-1,2,4-triazoles via base-promoted [3 + 2] cycloaddition of nitrile imines and 1H-benzo[d]imidazole-2-thiols-Reference-Cited by-同舟云学术

Synthesis of fused 3-trifluoromethyl-1,2,4-triazoles via base-promoted [3 + 2] cycloaddition of nitrile imines and 1H-benzo[d]imidazole-2-thiols

Published:2023 Issue:35 Volume:21 Page:7095-7099
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cen Kaili¹,Wei Jiahao²,Feng Yuting³,Liu Yuan³,Wang Xinye³^ORCID,Liu Yangyu³,Yin Yalin¹,Yu Junhong¹,Wang Dahan⁴^ORCID,Cai Jinhui¹^ORCID

Affiliation:

1. College of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, Hunan, China

2. School of Pharmaceutical Science, University of South China, Hengyang 421001, Hunan, China

3. Chuanshan College University of South China, Hengyang 421001, Hunan, China

4. Department of Food and Chemical Engineering, Shaoyang University, Shaoyang 422100, Hunan, China

Abstract

This work describes the facile synthesis of fused 3-trifluoromethyl-1,2,4-triazoles via triethylamine-promoted [3 + 2] dipolar cycloaddition of nitrile imines with 1H-benzo[d]imidazole-2-thiols.

Funder

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01133J

Reference57 articles.

1. Applications of Fluorine in Medicinal Chemistry

2. Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules

3. The Many Roles for Fluorine in Medicinal Chemistry

4. Fluorine in medicinal chemistry

5. Transition-Metal-Free N–O Reduction of Oximes: A Modular Synthesis of Fluorinated Pyridines

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A facile growth, optical behavior of organic nonlinear optical crystal: 4-bromo-2-methylbenzonitrile;MRS Advances;2024-01-04

2. Trifluoromethylated hydrazones and acylhydrazones as potent nitrogen-containing fluorinated building blocks;Beilstein Journal of Organic Chemistry;2023-11-15

3. ω-(3-Trifluoromethylpyrazol-4-yl)alkanoic acids via (3 + 2)-cycloaddition of nitrile imines with cyclic enones and deacylative aromatization;Journal of Fluorine Chemistry;2023-11

4. (3+2)-Cycloadditions of Levoglucosenone (LGO) with Fluorinated Nitrile Imines Derived from Trifluoroacetonitrile: An Experimental and Computational Study;Molecules;2023-10-30