Copper(<scp>ii</scp>)-catalyzed direct dehydrative alkynylation of 2<i>H</i>-chromene hemiketals with terminal alkynes to 2,2-disubstituted 2-alkynylated 2<i>H</i>-chromenes-Reference-Cited by-同舟云学术

Copper(ii)-catalyzed direct dehydrative alkynylation of 2H-chromene hemiketals with terminal alkynes to 2,2-disubstituted 2-alkynylated 2H-chromenes

Published:2022 Issue:18 Volume:20 Page:3785-3789
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zheng Shi-Lu¹²,Wen Zhong²³,Yang Kai-Cheng²³,Zeng Yao²³,Chen Long²³^ORCID,Deng Jun-Feng²³

Affiliation:

1. College of Food and Biological Engineering, Chengdu University, 2025 Chengluo Avenue, Chengdu 610016, P. R. China

2. Institute for Advanced Study, Chengdu University, 2025 Chengluo Avenue, Chengdu 610016, P. R. China

3. Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, 2025 Chengluo Avenue, Chengdu 610016, P. R. China

Abstract

The first copper-catalyzed dehydrative alkynylation of 2H-chromene hemiketals with aryl and alkyl terminal alkynes is reported, which provides 2,2-disubstituted 2-alkynylated 2H-chromenes with rich diversity in up to 83% yield.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00481J

Reference63 articles.

1. Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

2. Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans

3. Bioactive Carbazole Alkaloids from Clausena wallichii Roots

4. Flemingins G–O, Cytotoxic and Antioxidant Constituents of the Leaves of Flemingia grahamiana

5. 4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions

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