A bioartificial liver support system integrated with a DLM/GelMA-based bioengineered whole liver for prevention of hepatic encephalopathy via enhanced ammonia reduction

Author:

Wu Guohua12345,Wu Di12345,Lo James6789ORCID,Wang Yimin12345,Wu Jianguo12345,Lu Siming12345,Xu Han10111213,Zhao Xin141513ORCID,He Yong1617181913ORCID,Li Jun12345,Demirci Utkan2021222324,Wang Shuqi12345ORCID

Affiliation:

1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases

2. National Clinical Research Center for Infectious Diseases

3. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases

4. The First Affiliated Hospital

5. College of Medicine

6. Department of Bioengineering

7. University of California Berkeley

8. Berkeley

9. USA

10. Department of Building Environment and Energy Engineering

11. Xi'an Jiaotong University

12. Xian

13. China

14. Department of Biomedical Engineering

15. The Hong Kong Polytechnic University

16. State Key Laboratory of Fluid Power and Mechatronic Systems

17. Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical Engineering

18. Zhejiang University

19. Hangzhou

20. Bio-Acoustic MEMS in Medicine (BAMM) Laboratory

21. Canary Center at Stanford for Cancer Early Detection

22. Department of Radiology

23. Stanford University

24. School of Medicine

Abstract

The developed bioartificial liver support system integrated with the decellularized liver matrix/GelMA-based bioengineered whole liver can potentially help elevate liver functions and prevent hepatic encephalopathy via enhanced ammonia reduction.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

National Key Scientific Instrument and Equipment Development Projects of China

National Major Science and Technology Projects of China

Key Research and Development Program of Jiangxi Province

Hong Kong Polytechnic University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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