Overview of alkyl quercetin lipophenol synthesis and its protective effect against carbonyl stress involved in neurodegeneration

Author:

Otaegui Léa12,Lehoux Jordan2,Martin Leo2,Givalois Laurent13ORCID,Durand Thierry2ORCID,Desrumaux Catherine14,Crauste Céline2ORCID

Affiliation:

1. MMDN, Univ Montpellier, INSERM, EPHE, Montpellier, France

2. IBMM, Univ Montpellier, CNRS, ENSCM, 34000 Montpellier, France

3. Laval University, Department of Neurosciences & Psychiatry, Quebec, Canada

4. LIPSTIC LabEx, 21000 Dijon, France

Abstract

Chemical and chemo-enzymatic pathways were developed for the synthesis of alkyl quercetin lipophenol, aiming to produce a potent lipidic antioxidant effective against carbonyl stress toxicity.

Funder

Université de Montpellier

Agence Nationale de la Recherche

Conseil régional de Bourgogne-Franche-Comté

European Regional Development Fund

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

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