Extravasation of Pt-based chemotherapeutics – bioimaging of their distribution in resectates using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS)

Author:

Egger Alexander E.12345,Kornauth Christoph675,Haslik Werner8975,Hann Stephan1011125,Theiner Sarah345134,Bayer Günther675,Hartinger Christian G.3451415,Keppler Bernhard K.345134,Pluschnig Ursula1617718,Mader Robert M.1617718

Affiliation:

1. ADSI – Austrian Drug Screening Institute GmbH

2. Innsbruck, Austria

3. Institute of Inorganic Chemistry

4. University of Vienna

5. Vienna, Austria

6. Institute of Clinical Pathology

7. Comprehensive Cancer Center of the Medical University of Vienna

8. Department of Surgery

9. Division of Plastic and Reconstructive Surgery

10. Department of Chemistry

11. Division of Analytical Chemistry

12. University of Natural Resources and Life Sciences (BOKU)

13. Research Platform ‘Translational Cancer Therapy Research’

14. School of Chemical Sciences

15. University of Auckland

16. Department of Medicine I

17. Clinical Division of Oncology

18. 1090 Vienna, Austria

Abstract

Spatially resolved quantification of platinum distribution in patients that exhibited extravasation was feasible up to 4 weeks upon drug application.

Funder

Austrian Science Fund

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

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