Quantified electrostatic preorganization in enzymes using the geometry of the electron charge density
Author:
Affiliation:
1. Molecular Theory Group
2. Colorado School of Mines
3. USA
4. Department of Chemistry and Biochemistry
5. University of California
6. Los Angeles
Abstract
The exact positions of critical points in the charge density in enzyme active sites reflects electrostatic preorganization.
Funder
Office of Naval Research Global
Division of Chemistry
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC01301A
Reference39 articles.
1. Production of the antimalarial drug precursor artemisinic acid in engineered yeast
2. Electrostatic Origin of the Catalytic Power of Enzymes and the Role of Preorganized Active Sites
3. Electrostatic Basis for Enzyme Catalysis
4. The role of reorganization energy in rational enzyme design
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