Integrated <i>in silico</i> – <i>in vitro</i> strategy for the discovery of potential xanthine oxidase inhibitors from Egyptian propolis and their synergistic effect with allopurinol and febuxostat-Reference-Cited by-同舟云学术

Integrated in silico – in vitro strategy for the discovery of potential xanthine oxidase inhibitors from Egyptian propolis and their synergistic effect with allopurinol and febuxostat

Published:2022 Issue:5 Volume:12 Page:2843-2872
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Ghallab Dina S.¹,Shawky Eman¹^ORCID,Metwally Ali M.¹,Celik Ismail²,Ibrahim Reham S.¹^ORCID,Mohyeldin Mohamed M.¹

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38039, Turkey

Abstract

Xanthine oxidase (XO) has been well-recognized as a validated target for the treatment of hyperuricemia and gout.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA08011C

Reference65 articles.

1. Xanthine oxidase inhibitors beyond allopurinol and febuxostat; an overview and selection of potential leads based on in silico calculated physico-chemical properties, predicted pharmacokinetics and toxicity

2. Longevity and aging. Role of free radicals and xanthine oxidase. A review

3. The Xanthine Oxidase Inhibitory Activity and Hypouricemic Effects of Crude Drugs Obtained from the Silkworm in Mice

4. Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

5. Pathogenesis of Gout

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