Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells-Reference-Cited by-同舟云学术

Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells

Published:2016 Issue:39 Volume:14 Page:9278-9286
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kelly G. J.¹²³⁴⁵^ORCID,Kia A. Foltyn-Arfa⁶⁷⁸⁵,Hassan F.⁹³⁴⁵,O'Grady S.⁹³⁴⁵,Morgan M. P.⁹³⁴⁵,Creaven B. S.⁶⁷⁸⁵,McClean S.¹⁰⁷⁸⁵,Harmey J. H.⁹³⁴⁵,Devocelle M.¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Synthesis and Chemical Biology

2. Department of Pharmaceutical and Medicinal Chemistry

3. Royal College of Surgeons in Ireland

4. Dublin 2

5. Ireland

6. Department of Science

7. Institute of Technology Tallaght

8. Dublin 24

9. Molecular and Cellular Therapeutics

10. Centre of Microbial Host Interactions

Abstract

The first targeted anticancer polymeric prodrug candidates of antimicrobial peptides, intended for combination therapy with another polymeric prodrug of an approved antineoplastic agent (doxorubicin) are reported.

Funder

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01815G

Reference30 articles.

1. Antimicrobial peptides of multicellular organisms

2. Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment

3. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies