1-(N,N-Dialkylcarbamoyl)-1,1-difluoromethanesulfonyl ester as a stable and effective precursor for a neopentyl labeling group with astatine-211

Author:

Sasaki Ichiro1,Tada Masatoshi2,Liu Ziyun2ORCID,Tatsuta Maho2,Okura Takeru2,Aoki Miho3,Takahashi Kazuhiro3,Ishioka Noriko S.1,Watanabe Shigeki1ORCID,Tanaka Hiroshi2ORCID

Affiliation:

1. Department of Quantum-Applied Biosciences, Takasaki Institute for Advanced Quantum Science National Institutes for Quantum Science and Technology, 1233 Watanuki-machi, Takasaki, Gunma 370-1292, Japan

2. Department of Chemical Science and Engineering, Tokyo Institute of Technology, 12-12-1-H101 Ookayama, Meguro, Tokyo, 152-8552, Japan

3. Advanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikariga-oka, Fukushima, Fukushima 960-1295, Japan

Abstract

Replacement of a fluoride atom with a carbonyl group allows easy handling and efficient radiolabeling.

Funder

Japan Science and Technology Corporation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference28 articles.

1. Radiotheranostics: a roadmap for future development

2. Radiotheranostics - Precision Medicine in Nuclear Medicine and Molecular Imaging

3. N. S.Mason and C. A.Mathis , Radiohalogens for PET imaging , in Positron Emission Tomopgrphay , ed. D. L. Bailey , D. W. Townsend , P. E. Valk and M. N. Maisey , Springer-Verlag , London , 2003 , pp. 217

4. Radiohalogens for imaging and therapy

5. Astatine

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