Amphiphile catalysed selective synthesis of 4-amino alkylated-1H-pyrazol-5-ol via Mannich aromatization preferred to the Knoevenagel–Michael type reaction in water-Reference-Cited by-同舟云学术

Amphiphile catalysed selective synthesis of 4-amino alkylated-1H-pyrazol-5-ol via Mannich aromatization preferred to the Knoevenagel–Michael type reaction in water

Published:2014 Issue:101 Volume:4 Page:57953-57957
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Kumar Atul¹²³⁴⁵,Maurya Shivam¹²³⁴⁵,Gupta Maneesh Kumar¹²³,Shukla Ratnakar Dutt¹²³

Affiliation:

1. Medicinal and Process Chemistry Division

2. CSIR-Central Drug Research Institute

3. Lucknow-226031, India

4. Academy of Scientific & Innovative Research (AcSIR)

5. New Delhi, India

Abstract

An economic and efficient amphiphile (SDS) catalysed one pot synthesis of aromatized 4-amino alkylated-1H-pyrazol-5-ol via a Mannich aromatization preffered to the Knoevenagel–Michael type reaction in water has been developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA11961D

Reference50 articles.

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2. Synthesis and Structure–Activity Relationship (SAR) of (5,7-Disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT6 Receptor (5-HT6R) Antagonists

3. The c-Jun N-Terminal Protein Kinase Signaling Pathway Mediates Bax Activation and Subsequent Neuronal Apoptosis through Interaction with Bim after Transient Focal Cerebral Ischemia

4. Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

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