The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells-Reference-Cited by-同舟云学术

The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells

Published:2019 Issue:3 Volume:10 Page:665-673
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Iosub-Amir Anat¹²³⁴,Bai Fang⁵⁶⁷⁸⁹^ORCID,Sohn Yang-Sung¹⁰²³⁴,Song Luhua¹¹¹²¹³⁹,Tamir Sagi¹⁰²³⁴,Marjault Henri-Baptiste¹⁰²³⁴,Mayer Guy¹²³⁴,Karmi Ola¹⁰²³⁴,Jennings Patricia A.¹⁴¹⁵¹⁶⁹,Mittler Ron¹⁷¹⁸¹⁹²⁰²¹^ORCID,Onuchic José N.⁵⁶⁷⁸⁹,Friedler Assaf¹²³⁴^ORCID,Nechushtai Rachel¹⁰²³⁴

Affiliation:

1. Institute of Chemistry

2. The Hebrew University of Jerusalem

3. Jerusalem 91904

4. Israel

5. Center for Theoretical Biological Physics

6. Department of Physics

7. Rice University

8. Houston

9. USA

10. The Alexander Silberman Institute of Life Science

11. Department of Biological Sciences

12. University of North Texas

13. Denton

14. Department of Chemistry & Biochemistry

15. University of California at San Diego

16. La Jolla

17. Department of Surgery

18. University of Missouri School of Medicine

19. Christopher S. Bond Life Sciences Center

20. University of Missouri

21. Columbia

Abstract

We reveal a novel interaction between the two anti-apoptotic proteins iASPP and NAF-1, which are overexpressed in many types of cancer cells, and propose that this interaction is required for apoptosis activation in cancer cells. A peptide derived from the interaction interface inhibits apoptosis in cells.

Funder

National Science Foundation

Israel Science Foundation

Israel Cancer Research Fund

Hebrew University of Jerusalem

National Institutes of Health

Cancer Prevention and Research Institute of Texas

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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