High throughput mechanochemistry: application to parallel synthesis of benzoxazines

Author:

Martina K.12345,Rotolo L.12345,Porcheddu A.6785ORCID,Delogu F.910111213ORCID,Bysouth S. R.141516,Cravotto G.12345ORCID,Colacino E.12345ORCID

Affiliation:

1. Dipartimento di Scienza e Tecnologia del Farmaco and NIS

2. Centre for Nanostructured Interfaces and Surfaces

3. University of Turin

4. Turin

5. Italy

6. Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari

7. Cittadella Universitaria

8. 09028 Monserrato (Ca)

9. Dipartimento di Ingegneria Meccanica

10. Chimica

11. e dei Materiali

12. Università degli Studi di Cagliari

13. 09123 Cagliari

14. Automaxion SARL

15. 50250 Varenguebec

16. France

Abstract

Mechanochemical “parallel synthesis”: processing 12 samples simultaneously allowed fast screening of the optimum reaction conditions and high throughput preparation of benzozaxine derivatives, including a fungicide.

Funder

Fondazione Banco di Sardegna

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference48 articles.

1. The historical development of mechanochemistry

2. A. D. W. McNaught and A.Wilkinson , Chemical reaction that is induced by the direct absorption of mechanical energy , IUPAC Compendium of Chemical Terminology (“The Golden Book ”), Blackwell Scientific Publications , Oxford , 2nd edn, 1997

3. Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins

4. Scale-up of organic reactions in ball mills: process intensification with regard to energy efficiency and economy of scale

5. Mechanochemical Organic Synthesis , ed. D. Margetic and V. Štrukil , Elsevier , 2016

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