Amine-catalyzed site- and stereo-selective coupling of epoxy amines and carbon dioxide to construct oxazolidinones-Reference-Cited by-同舟云学术

Amine-catalyzed site- and stereo-selective coupling of epoxy amines and carbon dioxide to construct oxazolidinones

Published:2022 Issue:16 Volume:9 Page:4294-4300
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Qiu Wenqin¹,Jin Feng¹,Hao Yanhong¹,Bao Xiaoguang¹^ORCID,Yuan Dan¹^ORCID,Yao Yingming¹^ORCID

Affiliation:

1. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Abstract

NEt3 catalyzed the cycloaddition of epoxy amine and CO2, which generated oxazolidinones. Reactions of chiral epoxy amine achieved 100% configuration inversion, enabling the synthesis of linezolid. DFT studies show that NEt3 acted as a nucleophile.

Funder

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO00583B

Reference39 articles.

1. Synthesis and Structure−Activity Relationship Studies of Highly Potent Novel Oxazolidinone Antibacterials

2. Efficacy of the novel oxazolidinone compound FYL-67 for preventing biofilm formation by Staphylococcus aureus