Discovery of benthol A and its challenging stereochemical assignment: opening up a new window for skeletal diversity of super-carbon-chain compounds

Author:

Jiang Zhong-Ping1234,Sun Shi-Hao1234,Yu Yi56784,Mándi Attila9101112ORCID,Luo Jiao-Yang1314151617,Yang Mei-Hua1314151617,Kurtán Tibor9101112ORCID,Chen Wen-Hua1819204,Shen Li56784ORCID,Wu Jun1234ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Southern Medical University

3. Guangzhou 510515

4. P. R. China

5. Marine Drugs Research Center

6. College of Pharmacy

7. Jinan University

8. Guangzhou 510632

9. Department of Organic Chemistry

10. University of Debrecen

11. 4002 Debrecen

12. Hungary

13. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine

14. Ministry of Education

15. Institute of Medicinal Plant Development

16. Chinese Academy of Medical Sciences

17. Peking Union Medical College

18. School of Biotechnology and Health Sciences

19. Wuyi University

20. Jiangmen

Abstract

The discovery of benthol A, a marine natural product featuring thirty-five carbon stereocenters and eight scattered ether rings within a C72 backbone chain, inaugurates a new family of super-carbon-chain compounds.

Funder

European Regional Development Fund

National Natural Science Foundation of China

Nemzeti Kutatási Fejlesztési és Innovációs Hivatal

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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