A stable physisorbed layer of packed capture antibodies for high-performance sensing applications

Author:

Sarcina Lucia1ORCID,Scandurra Cecilia1ORCID,Di Franco Cinzia2,Caputo Mariapia3ORCID,Catacchio Michele3,Bollella Paolo14ORCID,Scamarcio Gaetano54,Macchia Eleonora346ORCID,Torsi Luisa146ORCID

Affiliation:

1. Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy

2. CNR – Institute of Photonics and Nanotechnologies, 70126 Bari, Italy

3. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, 70126 Bari, Italy

4. CSGI (Centre for Colloid and Surface Science), Via E. Orabona 4, 70125 Bari, Italy

5. Dipartimento Interateneo di Fisica “M. Merlin”, Università degli Studi di Bari Aldo Moro, 70126 Bari, Italy

6. The Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland

Abstract

The uniformity and long-term stability of physisorbed antibodies against SARS-CoV-2-Spike1 at a solid interface are addressed. High-performance sensing is accomplished, outmatching the analytical performance achieved with the chemical bonding of capture antibodies.

Funder

Horizon 2020 Framework Programme

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry

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