Dual-functionalisation of gelatine nanoparticles with an anticancer platinum(ii)–bisphosphonate complex and mineral-binding alendronate

Author:

Farbod Kambiz12345ORCID,Curci Alessandra6789,Diba Mani12345,Zinkevich Tatiana101112135,Kentgens Arno P. M.101112135,Iafisco Michele1415169,Margiotta Nicola6789,Leeuwenburgh Sander C. G.12345

Affiliation:

1. Department of Biomaterials

2. Radboud Institute for Molecular Life Sciences

3. Radboud University Medical Center

4. 6525 EX Nijmegen

5. The Netherlands

6. Dipartimento di Chimica

7. Università degli Studi di Bari Aldo Moro

8. 70125 Bari

9. Italy

10. Department of Solid State NMR

11. Institute for Molecules and Materials

12. Radboud University

13. 6525 AJ Nijmegen

14. Institute of Science and Technology for Ceramics (ISTEC)

15. National Research Council (CNR)

16. 48018 Faenza

Abstract

Mineral-binding gelatine nanoparticles can be loaded with tailored amounts of anticancer molecules, which may benefit the development of bone-seeking carriers for targeted delivery of drugs to treat bone tumours.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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