A copper–platinum nanoplatform for synergistic photothermal and chemodynamic tumor therapy via ROS outburst and GSH exhaustion

Author:

Li Chao1,Jia Wenqing23,Guo Zichao23,Kang Yan1,Zhou Chaohui1,Zhao Ren23,Cheng Xi23,Jia Nengqin1ORCID

Affiliation:

1. The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, Shanghai Frontiers Science Center of Biomimetic Catalysis, and Shanghai Key Laboratory of Rare Earth Functional Materials, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China

2. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

3. Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

Abstract

The Cu-HCF-HA@Pt nanoplatform cause apoptosis via its dual-enzyme activity, photothermal properties, and Fenton-like reaction, which generates hydroxyl radicals, exhausts intracellular glutathione to achieve the effect of synergistic treatment.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

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