Assembly of catechol-modified polymer brushes for drug delivery

Author:

Zhao Kaijie1ORCID,Gao Zhiliang1ORCID,Song Dongpo2,Zhang Peiyu1ORCID,Cui Jiwei13ORCID

Affiliation:

1. Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China

2. Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China

3. State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China

Abstract

The anticancer drug of Bortezomib conjugated onto catechol-modified bottlebrush block copolymers can be intracellularly released owing to the pH-responsive behavior, resulting in considerable cell death and tumor growth inhibition.

Funder

National Natural Science Foundation of China

Jinan Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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